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Lorcaserin hydrochloride

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Lorcaserin hydrochloride

CAS number 1431697-94-7

Molecular formulaC11H15Cl2N

Molecular weight 232.14900

Packing: 1kg/bag or 25kg/drum

Valid time: 2 years

Specification:

ITEMS

Specification

RESULT

Appearance

white or off-white powder

off-white powder

Identification

HPLC retention time

Conforms

Melting Point

225-229

226

Loss on drying

1.0%

0.43%

Residue on ignition

0.5%

0.13%

Residual Solvents

Ethanol0.5%

0.11%

EA0.5%

0.06%

Related Substances

Single impurity 0.5%

0.21%

Total impurity 1.0%

0.39%

Assay (HPLC)

99.0 %

99.6%

Conclusion

Conforms to Enterprise Standard

 

 

Function: 

Lorcaserin hcl is an FDA-approved prescription weight-loss medication that, when used with diet and exercise, can help some overweight adults with a weight-related medical problem, or obese adults, lose weight and keep it off. It is not known if Lorcaserin hcl when taken with other prescription, over-the-counter, or herbal weight-loss products is safe and effective. It is not known if Lorcaserin hcl changes your risk of heart problems, stroke, or death due to heart problems or stroke.


Lorcaserin is a selective 5-HT2C receptor agonist, and in vitro testing of the drug showed reasonable selectivity for 5-HT2C over other related targets. 5-HT2C receptors are located almost exclusively in the brain, and can be found in the choroid plexus, cortex, hippocampus, cerebellum, amygdala, thalamus, andhypothalamus. The activation of 5-HT2C receptors in the hypothalamus is supposed to activate proopiomelanocortin(POMC) production and consequently promote weight loss through satiety. This hypothesis is supported by clinical trials and other studies. While it is generally thought that 5-HT2C receptors help to regulate appetite as well as mood, and endocrine secretion, the exact mechanism of appetite regulation is not yet known. Lorcaserin has shown 100x selectivity for 5-HT2C versus the closely related 5-HT2B receptor.


Application: 

Lorcaserin hcl is an FDA-approved prescription weight-loss medication that, when used with diet and exercise, can help some overweight adults with a weight-related medical problem, or obese adults, lose weight and keep it off.

lorcaserin hydrochlorideis a serotonin 2C receptor agonist. It has been shown to decrease food consumption and promote sa tiety by selectivelyactivating serotonin 2C receptors in the brain.

Lorcaserin hcl is specifically indicated as an adjunct to a reduced-calorie diet andincreased physical activity for chronic weight management in clinically obeseadults (BMI of 30 kg/m2 or greater) and overweight adults (BMI of 27 kg/m2 orgreater) with at least one weight-related comorbid condition.

Lorcaserin hcl is supplied as a tablet designed for oral administration. The recommendeddose is one 10mg tablet twice daily. Use of Lorcaserin hcl should be discontinued if 5%weight loss is not achieved by week 12 of treatment.

 


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