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Gentamycin Sulfate

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Gentamycin Sulfate

CAS number: 1405-41-0

Molecular formula: C21H45N5O11S

Molecular weight:1488.785

Shelf Life: 4 years

Packing: 5BOU/Bag, 2Bags/Drum or 5BOU/tin, 2Tins/Drum

Quality: please kindly download in our website

Specification:

Items

Specifications

Results

Characters

A white or almost white powder, freely soluble in water,

Practically insoluble in alcohol and in ether.

PASS

Identification

Positive Reaction

PASS

Appearance of solution

Clear and not more intensely colored than degree 6 of the range of reference solutions of the most appropriate color

PASS

Acidity(PH)

3.5 to 5.5

4.4

Specific Optical Rotation

+107°to +121°

+114°

Methanol

Not more than 1.0 percent

PASS

Composition

C1   25.0 to 50.0 percent

25.8%

C1a   10.0 to 35.0 percent

28.6%

C2a+C2   25.0 to 55.0 percent

45.6%

Water

Not more than 15.0 percent

8.4%

Sulphate Ash

Not more than 1.0 percent

0.5%

Sulphate

32.0 to 35.0 percent

33.9%

Bacterial endotoxins

Less than 1.67 IU/mg

<0.71 IU/mg

Assay

not less than 590 IU/mg (Anhydrous substance)

653  IU/mg

Hydrous substance

598  IU/mg

Conclusion: Complies With The standard of The British Pharmacopoeia 2002.

 

 

 

 Function 

Gentamycin Sulfate is applicable to pseudomonas aeruginosa, proteus, klebsiella species, e. coli, Mr Charest bacteria genera, citrate coli and staphylococcus aureus in neonatal sepsis, septicemia, central nervous system infections, respiratory tract infection, urinary tract infection, reproductive system infection, infection of biliary tract, skin, bones, otitis media, sinusitis, soft tissue infection, etc.; Gentamicin sulfate is suitable for the central and external infection caused by sensitive bacteria. The main application is as follows:
1.Gentamycin Sulfate used in the treatment of respiratory tract infection caused by sensitive bacteria infection, biliary infection, intestinal infection, abdominal cavity infection, urinary reproductive system infection (with the exception of simple urinary tract infection treated first), skin and soft tissue infection, burn infection and neonatal sepsis, and sepsis.
2.Gentamycin Sulfate used in the treatment of listeriosis.
3.Gentamycin Sulfate Intramuscular injection in parallel with clindamycin or metronidazole can be used to reduce the incidence of infection after colon surgery.
4.The injection of gentamycin sulfate can be used as an adjuvant therapy for severe central nervous system infection (meningitis, encephalitis) caused by pseudomonas aeruginosa or staphylococcus aureus.
5.Gentamycin Sulfate Oral administration can be used to treat bacterial dysentery or other bacterial intestinal infections, and may also be used before colonic surgery.
6.Gentamycin Sulfate used as eye drops for conjunctivitis, keratitis, dacryocystitis, blepharitis, sty, meibomian gland inflammation and corneal ulcer, etc, which is caused by coagulase negative and positive,staphylococcus aureus, pseudomonas aeruginosa, escherichia coli, streptococcus pneumonia, flu bacilli and other caused by gram-negative bacilli or gonococcal.

 

 Application: 

Gentamycin Sulfate is an important member of the Aminoglycoside Antibiotic,Gentamycin Sulfate is widespread used in the treatment of diseases caused by pseudomonas aeruginosa , proteus,Bacillus Coli, Klebsiella, Serratia and staphylococcus, e.g. pyemia of newborn baby, septicemia, infections of central nervous system, urethra, respiratory tract, alimentary infection, skin, bone and soft tissue.

 


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