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Florfenicol

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Florfenicol

CAS number: 73231-34-2

Molecular formula:C12H14Cl2FNO4S

molecular weight:358.21

Packing: 25kg/drum

Shelf Life: 2 years

Specification:

 Tests

 Acceptance Criteria

Results

 Characters

white or almost white crystalline powder

Conforms

Melting point

152 ~ 156℃

154.5-155.5℃

Specific optical rotation

-16°~ -19°

-17.7°

Identification

The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation obtained as specified in the Assay

Conforms

IR:红外光吸收图谱应与对照的图谱一致

IR: Conforms to the reference spectra

PH

4.5 ~ 6.5

5.8

Clarity of solution

Not more than reference suspension II

Conforms

Color of solution

Not more intensely coloured than Y5 or YG5

Conforms

Chloride

≤0.02%

<0.02%

Fluoride

≥4.8%

5.0%

Related substances(HPLC)

单个杂质Any single impurity ≤0.5%

0.19%

总杂质Total impurities ≤2.0%

0.59%

Water

≤0.5%

0.03%

Residue on ignition

≤0.1%

0.05%

Heavy metals

≤20ppm

<20ppm

Assay

C12H14Cl2FNO4S  ≥98.0%(on the anhydrous substance)

99.8%

Conclusion

 conforms to CVP2015 for Flofenicol

 

Function:

1. For pigs arthritis, pneumonia, atrophic rhinitis and other diseases caused by streptococcus, pneumococcal, haemophilus.
2. High fever, breathing difficult, septicemia caused by eperythrozoonasthmalung plaguechlamydiatoxoplasmaspirochete.
3. Auxiliary treatment of breathing and reproduction obstacle syndrome, Aujeszky's Disease, bacterial infection caused by
influenza.

Indications

1. The goods as one of the drugs used for the following diseases:
(1) rickettsial diseases, such as epidemic typhus, endemic typhus, Rocky Mountain fever, scrub typhus and Q fever.
(2) are infected with Chlamydia, including psittacosis, sexually transmitted diseases, tooth swollen lymph meat, non-specific
urethritis, salpingitis, cervicitis, and trachoma.

(3) Mycoplasma infection.
(4) relapsing fever.

(5) plague.
(6) cholera.

(7) brucellosis.
(8) rabbit fever.
(9) chancroid. Treatment of brucellosis and plague combined when necessary with the aminoglycosides.
2. As the current common pathogenic bacteria resistant to tetracycline class is serious, only sensitive to the chemicals in the pathogen, the parties have applied indication. Staphylococcus most resistant to the chemicals. 3. This product can be used for patients with penicillin allergy tetanus, gas gangrene, yaws, syphilis, gonorrhea and leptospirosis, and Actinomyces spp, Listeria monocytogenes infection.
4. Can be used in patients with severe acne as adjunctive therapy.

 


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