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Estradiol Benzoate

Quantity:

Estradiol Benzoate

CAS number: 50-50-0

Molecular formula: C25H28O3

Molecular weight: 376.49

Packing: 2kg/BAG/CARTON

Shelf Life: 4 years

Specification:

Test Itemes

Specification

Results

Characteristics

White to off-white, crystalline powder

Conform

Solubility

Soluble in alcohol and acetone, slightly soluble in ether, insoluble in water

Conform

Identification

A: IR; B: HPLC

Conform

Specific optical rotation

+57.0°- +63.0°

+58.76°

Loss on drying

≤0.50%

0.16%

Residue on ignition

≤0.2%

0.10%

Limit of methanol and dichloromethane

≤0.20%

0.10%

Chromatographic purity

Any impurity

Total impurity

 

≤1.0%

≤2.0%

 

0.19%

0.28%

Residual solvents

Benzoyl chloride

Ethyl acetate

Ethyl ether

 

≤500ppm

≤5000ppm

≤5000ppm

 

210ppm

370ppm

410ppm

Assay

97.0% -103.0%

99.63%

Micron


100%≤2.0μm

Conclusion

Conform the USP39 Standard

 

 

Function:

Estradiol benzoate is mainly used to supplement estrogen deficiency, such as atrophic vaginitis, vaginal dryness, female gonadal dysfunction, vulvar dryness, menopausal vasomotor symptoms, ovariectomy, primary ovarian failure, etc. Amenorrhea, menopausal syndrome, withdrawal of milk and prostate cancer, etc. 

Application:

 

Estradiol benzoate is an estrogenic drug. The same effect as estradiol, can make endometrial hyperplasia, enhance contraction of uterine smooth muscle, promote breast growth and proliferation: large doses of prolactin inhibition, anti-androgen effect, and increase calcium deposition in bone. This product is mainly metabolized in the liver, which is decomposed into estradiol, and partially binds to sex hormone binding globulin (SHBG). The unconjugated free part binds to the target tissue and estrogen receptor, which produces estrogenic effect through transcription and protein synthesis. In the liver or kidney, estrogen binds to glucuronic acid or sulfuric acid and becomes a water-soluble salt which is quickly discharged from the kidney.


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