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Estradiol Benzoate
CAS number： 50-50-0
Molecular formula： C25H28O3
Molecular weight： 376.49
Packing: 2kg/BAG/CARTON
Shelf Life: 4 years
Specification:
Test Itemes | Specification | Results |
Characteristics | White to off-white, crystalline powder | Conform |
Solubility | Soluble in alcohol and acetone, slightly soluble in ether, insoluble in water | Conform |
Identification | A: IR; B: HPLC | Conform |
Specific optical rotation | +57.0°- +63.0° | +58.76° |
Loss on drying | ≤0.50% | 0.16% |
Residue on ignition | ≤0.2% | 0.10% |
Limit of methanol and dichloromethane | 0.10% | |
Chromatographic purity Any impurity Total impurity |
≤1.0% ≤2.0% |
0.19% 0.28% |
Residual solvents Benzoyl chloride Ethyl acetate Ethyl ether |
≤500ppm ≤5000ppm ≤5000ppm |
210ppm 370ppm 410ppm |
Assay | 97.0% -103.0% | 99.63% |
Micron | 100%≤2.0μm | |
Conclusion | Conform the USP39 Standard | |
Function:
Estradiol benzoate is mainly used to supplement estrogen deficiency, such as atrophic vaginitis, vaginal dryness, female gonadal dysfunction, vulvar dryness, menopausal vasomotor symptoms, ovariectomy, primary ovarian failure, etc. Amenorrhea, menopausal syndrome, withdrawal of milk and prostate cancer, etc.
Application:
Estradiol benzoate is an estrogenic drug. The same effect as estradiol, can make endometrial hyperplasia, enhance contraction of uterine smooth muscle, promote breast growth and proliferation: large doses of prolactin inhibition, anti-androgen effect, and increase calcium deposition in bone. This product is mainly metabolized in the liver, which is decomposed into estradiol, and partially binds to sex hormone binding globulin (SHBG). The unconjugated free part binds to the target tissue and estrogen receptor, which produces estrogenic effect through transcription and protein synthesis. In the liver or kidney, estrogen binds to glucuronic acid or sulfuric acid and becomes a water-soluble salt which is quickly discharged from the kidney.
Estradiol Benzoate
CAS number： 50-50-0
Molecular formula： C25H28O3
Molecular weight： 376.49
Packing: 2kg/BAG/CARTON
Shelf Life: 4 years
Specification:
Test Itemes | Specification | Results |
Characteristics | White to off-white, crystalline powder | Conform |
Solubility | Soluble in alcohol and acetone, slightly soluble in ether, insoluble in water | Conform |
Identification | A: IR; B: HPLC | Conform |
Specific optical rotation | +57.0°- +63.0° | +58.76° |
Loss on drying | ≤0.50% | 0.16% |
Residue on ignition | ≤0.2% | 0.10% |
Limit of methanol and dichloromethane | 0.10% | |
Chromatographic purity Any impurity Total impurity |
≤1.0% ≤2.0% |
0.19% 0.28% |
Residual solvents Benzoyl chloride Ethyl acetate Ethyl ether |
≤500ppm ≤5000ppm ≤5000ppm |
210ppm 370ppm 410ppm |
Assay | 97.0% -103.0% | 99.63% |
Micron | 100%≤2.0μm | |
Conclusion | Conform the USP39 Standard | |
Function:
Estradiol benzoate is mainly used to supplement estrogen deficiency, such as atrophic vaginitis, vaginal dryness, female gonadal dysfunction, vulvar dryness, menopausal vasomotor symptoms, ovariectomy, primary ovarian failure, etc. Amenorrhea, menopausal syndrome, withdrawal of milk and prostate cancer, etc.
Application:
Estradiol benzoate is an estrogenic drug. The same effect as estradiol, can make endometrial hyperplasia, enhance contraction of uterine smooth muscle, promote breast growth and proliferation: large doses of prolactin inhibition, anti-androgen effect, and increase calcium deposition in bone. This product is mainly metabolized in the liver, which is decomposed into estradiol, and partially binds to sex hormone binding globulin (SHBG). The unconjugated free part binds to the target tissue and estrogen receptor, which produces estrogenic effect through transcription and protein synthesis. In the liver or kidney, estrogen binds to glucuronic acid or sulfuric acid and becomes a water-soluble salt which is quickly discharged from the kidney.
