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Doramectin

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Doramectin

CAS number: 117704-25-3

Molecular formula:C50H74O14

molecular weight: 899.11

Shelf Life: 2 years

Packing: 10kg/carton or 10kg/drum

Specification:

Items

Specifications

Results

Characters

White or off-white crystalline powder

Off-white crystalline powder

 

 

Identification

HPLC: The retention time of principal peak of sample conforms to that of reference

standard

 

complies

IR: Sample spectrum conforms to that of

reference standard.

complies

Clarity & Color of

Solution

The solution should be clear, and its color

depth isn’t more than the BY6

complies

Water

≤3.0%

1.5%

Heavy metals

≤20ppm

<20ppm

Sulphated Ash

≤0.1%

0.03%

 

 

 

 

Related Substances

Impurity 1

≤1.0%

Undetected

Impurity 2

≤2.0%

0.52%

Impurity 3

≤1.5%

0.63%

Impurity 4

≤1.0%

0.16%

Impurity 5

≤1.0%

0.13%

Any impurity

≤1.0%

0.65%

Total impurities

≤8.0%

3.73%

Assay (substance without water and

residual solvents)

 

≥92.0%

 

98%

BHT

≤2000ppm

105ppm

 

Residual solvents

Methanol

≤3000ppm

35ppm

Alcohol

≤30000ppm

15234ppm

Acetone

≤5000ppm

8ppm

 

Microbiological purity

Aerobic bacteria

≤1000cfu/g

≤10cfu/g

Fungi

≤100cfu/g

≤10cfu/g

Escherichia coli

absent

Undetected

Conclusion

Conform to the specification

 

 

 

 

Function:

It is used for the treatment and control of internal parasitosis (gastrointestinal and pulmonary nematodes), ticks and mange (and other ectoparasites). Doramectin is a derivative of ivermectin. Its spectrum includes:Haemonchus spp., Ostertagia spp., Trichostrongylusspp., Cooperia spp., Oesophagostomum spp., Dictyocaulus viviparus, Dermatobia hominis, Boophilus microplus,Psoroptes bovis, among many other internal and external parasites. It is available in 2 dosage forms: as aninjection and as a 5 mg/ml topical solution.
Doramectin is effective against the major parasitic roundworms: gastrointestinal and pulmonary. It is also effecive against most mites and lice species, and against numerous myiases (e.g. those caused by screwworm flies, bot flies and warble flies) usually regardless of the delivery form
As all macrocyclic lactone doramectin acts as agonist of the GABA (gamma-aminobutyric acid) neurotransmitter in nerve cells and also binds to glutamate-gated chloride channels in nerve and muscle cells of invertebrates. In both cases it blocks the transmission of neuronal signals of the parasites, which are either paralyzed and expelled out of the body, or they starve. It also affects the reproduction of some parasites by diminishing oviposition or inducing an abnormal oogenesis.

 


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