Doramectin
CAS number: 117704-25-3
Molecular formula:C50H74O14
molecular weight: 899.11
Shelf Life: 2 years
Packing: 10kg/carton or 10kg/drum
Specification:
Items | Specifications | Results | |
Characters | White or off-white crystalline powder | Off-white crystalline powder | |
Identification | HPLC: The retention time of principal peak of sample conforms to that of reference standard |
complies | |
IR: Sample spectrum conforms to that of reference standard. | complies | ||
Clarity & Color of Solution | The solution should be clear, and its color depth isn’t more than the BY6 | complies | |
Water | ≤3.0% | 1.5% | |
Heavy metals | ≤20ppm | <20ppm | |
Sulphated Ash | ≤0.1% | 0.03% | |
Related Substances | Impurity 1 | ≤1.0% | Undetected |
Impurity 2 | ≤2.0% | 0.52% | |
Impurity 3 | ≤1.5% | 0.63% | |
Impurity 4 | ≤1.0% | 0.16% | |
Impurity 5 | ≤1.0% | 0.13% | |
Any impurity | ≤1.0% | 0.65% | |
Total impurities | ≤8.0% | 3.73% | |
Assay (substance without water and residual solvents) |
≥92.0% |
98% | |
BHT | ≤2000ppm | 105ppm | |
Residual solvents | Methanol | ≤3000ppm | 35ppm |
Alcohol | ≤30000ppm | 15234ppm | |
Acetone | ≤5000ppm | 8ppm | |
Microbiological purity | Aerobic bacteria | ≤1000cfu/g | ≤10cfu/g |
Fungi | ≤100cfu/g | ≤10cfu/g | |
Escherichia coli | absent | Undetected | |
Conclusion | Conform to the specification |
Function:
It is used for the treatment and control of internal parasitosis (gastrointestinal and pulmonary nematodes), ticks and mange (and other ectoparasites). Doramectin is a derivative of ivermectin. Its spectrum includes:Haemonchus spp., Ostertagia spp., Trichostrongylusspp., Cooperia spp., Oesophagostomum spp., Dictyocaulus viviparus, Dermatobia hominis, Boophilus microplus,Psoroptes bovis, among many other internal and external parasites. It is available in 2 dosage forms: as aninjection and as a 5 mg/ml topical solution.
Doramectin is effective against the major parasitic roundworms: gastrointestinal and pulmonary. It is also effecive against most mites and lice species, and against numerous myiases (e.g. those caused by screwworm flies, bot flies and warble flies) usually regardless of the delivery form
As all macrocyclic lactone doramectin acts as agonist of the GABA (gamma-aminobutyric acid) neurotransmitter in nerve cells and also binds to glutamate-gated chloride channels in nerve and muscle cells of invertebrates. In both cases it blocks the transmission of neuronal signals of the parasites, which are either paralyzed and expelled out of the body, or they starve. It also affects the reproduction of some parasites by diminishing oviposition or inducing an abnormal oogenesis.
Doramectin
CAS number: 117704-25-3
Molecular formula:C50H74O14
molecular weight: 899.11
Shelf Life: 2 years
Packing: 10kg/carton or 10kg/drum
Specification:
Items | Specifications | Results | |
Characters | White or off-white crystalline powder | Off-white crystalline powder | |
Identification | HPLC: The retention time of principal peak of sample conforms to that of reference standard |
complies | |
IR: Sample spectrum conforms to that of reference standard. | complies | ||
Clarity & Color of Solution | The solution should be clear, and its color depth isn’t more than the BY6 | complies | |
Water | ≤3.0% | 1.5% | |
Heavy metals | ≤20ppm | <20ppm | |
Sulphated Ash | ≤0.1% | 0.03% | |
Related Substances | Impurity 1 | ≤1.0% | Undetected |
Impurity 2 | ≤2.0% | 0.52% | |
Impurity 3 | ≤1.5% | 0.63% | |
Impurity 4 | ≤1.0% | 0.16% | |
Impurity 5 | ≤1.0% | 0.13% | |
Any impurity | ≤1.0% | 0.65% | |
Total impurities | ≤8.0% | 3.73% | |
Assay (substance without water and residual solvents) |
≥92.0% |
98% | |
BHT | ≤2000ppm | 105ppm | |
Residual solvents | Methanol | ≤3000ppm | 35ppm |
Alcohol | ≤30000ppm | 15234ppm | |
Acetone | ≤5000ppm | 8ppm | |
Microbiological purity | Aerobic bacteria | ≤1000cfu/g | ≤10cfu/g |
Fungi | ≤100cfu/g | ≤10cfu/g | |
Escherichia coli | absent | Undetected | |
Conclusion | Conform to the specification |
Function:
It is used for the treatment and control of internal parasitosis (gastrointestinal and pulmonary nematodes), ticks and mange (and other ectoparasites). Doramectin is a derivative of ivermectin. Its spectrum includes:Haemonchus spp., Ostertagia spp., Trichostrongylusspp., Cooperia spp., Oesophagostomum spp., Dictyocaulus viviparus, Dermatobia hominis, Boophilus microplus,Psoroptes bovis, among many other internal and external parasites. It is available in 2 dosage forms: as aninjection and as a 5 mg/ml topical solution.
Doramectin is effective against the major parasitic roundworms: gastrointestinal and pulmonary. It is also effecive against most mites and lice species, and against numerous myiases (e.g. those caused by screwworm flies, bot flies and warble flies) usually regardless of the delivery form
As all macrocyclic lactone doramectin acts as agonist of the GABA (gamma-aminobutyric acid) neurotransmitter in nerve cells and also binds to glutamate-gated chloride channels in nerve and muscle cells of invertebrates. In both cases it blocks the transmission of neuronal signals of the parasites, which are either paralyzed and expelled out of the body, or they starve. It also affects the reproduction of some parasites by diminishing oviposition or inducing an abnormal oogenesis.