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Dexamethasone Sodium Phosphate

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Dexamethasone Sodium Phosphate

CAS number:55203-24-2

Molecular formula: C22H28FNa2O8P

Molecular weight: 516.40

Packing: 1kg/tin/carton; 2kg/tin/carton

Valid time: 3 years

Specification:

Test Items

Specifications 

Results

Appearance

White or almost white, very hygroscopic powder

Conform

Solubility

 

Freely soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride.

Conform

Appearance of Solution

Not more intensely coloured than reference solution B7

Conform

Identification

IR

The spectrum should be accord to the dexamethasone sodium phosphate CRS

Conform

TLC

The principal spot in the chromatogram obtained with test solution is similar in position and size to the principal spot in the chromatogram obtained with reference solution.

Conform

Identification

pH

7.5~9.5

8.7

Specific Optical Rotation

+75°~ +83°

+77.5°

Related substances

Impurity A≤ 0.5%

not detected

Impurity B≤ 0.5%

0.05%

Total impurities≤ 1.0%

0.79%

Ethanol and Water

≤ 13.0%

8.6%

Content

97.0 per cent to 103.0 per cent (anhydrous substance).

99.6%

Conclusion

To be conform with BP2010

 

Function of Dexamethasone sodium phosphate

1.Dexamethasone sodium phosphate is a synthetic adrenocortical steroid used to treat inflammatory and autoimmune 

   conditions;

2.Dexamethasone sodium phosphate is used to treat conditions such as skin conditions, ulcerative colitis, psoriasis, 

   arthritis, allergic disorders and breathing related problems;

3.Dexamethasone sodium phosphate is given to cancer patients undergoing chemotherapy, to prevent certain side-effects:

4.Dexamethasone sodium phosphate is also used in the treatment of high altitude cerebral edema.

 


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