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Clindamycin Hydrochloride, Clindamycin HCL
CAS number： 21462-39-5
Molecular formula： C18H33ClN2O5S.HCl;C18H34Cl2N2O5S
Molecular weight：461.44
Packing: 25kg/drum
Valid time: 3 years
Specification:
Analysis Items | Standard | Results |
[Description] | White or almost white, crystalline powder. | Conform |
[Identification] | ||
1) IR | The infrared absorption spectrum of Sample compare with the RS exhibits similar intensities of absorption at the same wave numbers. |
Conform |
2) HPLC | The retention time of the major peak of the sample solution corresponds to that of the standard solution. | Conform |
[Organic impurities] | ||
Clindamycin B 7-Epiclindamycin Any other individual impurity Total related compounds | ≤2.0% ≤4.0% ≤1.0% ≤6.0% | 0.9% 0.4% 0.3% 1.7% |
[Crystallinity] | Meets the requirements | Conform |
[pH] | 3.0～5.5,in a 100mg/ml solution | 4.2 |
[Water] | 3.0%～6.0% | 4.0% |
[Assay] | NLT 800μg/mg of C18H33ClN2O5S | 892μg/mg |
[Residual Solvents] | Ethanol≤0.5% | N.D. |
Acetone≤0.5% | 0.008% | |
Chloroform≤0.006% | N.D. | |
DMF≤0.088% | N.D. | |
Result：Conform to the requirements of USP40 standard | ||
Main Function
Clindamycin is used primarily to treat infections caused by susceptible anaerobic bacteria, including infections of the respiratory tract, skin and soft tissue infections, and peritonitis.In patients with hypersensitivity to penicillins, clindamycin may be used to treat infections caused by susceptible aerobic bacteria as well. It is also used to treat bone and joint infections, particularly those caused by Staphylococcus aureus. Topical application of clindamycin phosphate can be used to treat mild to moderate acne.
Application
It is a common topical treatment for acne and can be useful against some methicillin-resistant Staphylococcus aureus (MRSA) infections. The most severe common adverse effect of clindamycin is Clostridium difficile-associated diarrhea (the most frequent cause of pseudomembranous colitis). Although this side effect occurs with almost all antibiotics, including beta-lactam antibiotics, it is classically linked to clindamycin use.
Clindamycin Hydrochloride, Clindamycin HCL
CAS number： 21462-39-5
Molecular formula： C18H33ClN2O5S.HCl;C18H34Cl2N2O5S
Molecular weight：461.44
Packing: 25kg/drum
Valid time: 3 years
Specification:
Analysis Items | Standard | Results |
[Description] | White or almost white, crystalline powder. | Conform |
[Identification] | ||
1) IR | The infrared absorption spectrum of Sample compare with the RS exhibits similar intensities of absorption at the same wave numbers. |
Conform |
2) HPLC | The retention time of the major peak of the sample solution corresponds to that of the standard solution. | Conform |
[Organic impurities] | ||
Clindamycin B 7-Epiclindamycin Any other individual impurity Total related compounds | ≤2.0% ≤4.0% ≤1.0% ≤6.0% | 0.9% 0.4% 0.3% 1.7% |
[Crystallinity] | Meets the requirements | Conform |
[pH] | 3.0～5.5,in a 100mg/ml solution | 4.2 |
[Water] | 3.0%～6.0% | 4.0% |
[Assay] | NLT 800μg/mg of C18H33ClN2O5S | 892μg/mg |
[Residual Solvents] | Ethanol≤0.5% | N.D. |
Acetone≤0.5% | 0.008% | |
Chloroform≤0.006% | N.D. | |
DMF≤0.088% | N.D. | |
Result：Conform to the requirements of USP40 standard | ||
Main Function
Clindamycin is used primarily to treat infections caused by susceptible anaerobic bacteria, including infections of the respiratory tract, skin and soft tissue infections, and peritonitis.In patients with hypersensitivity to penicillins, clindamycin may be used to treat infections caused by susceptible aerobic bacteria as well. It is also used to treat bone and joint infections, particularly those caused by Staphylococcus aureus. Topical application of clindamycin phosphate can be used to treat mild to moderate acne.
Application
It is a common topical treatment for acne and can be useful against some methicillin-resistant Staphylococcus aureus (MRSA) infections. The most severe common adverse effect of clindamycin is Clostridium difficile-associated diarrhea (the most frequent cause of pseudomembranous colitis). Although this side effect occurs with almost all antibiotics, including beta-lactam antibiotics, it is classically linked to clindamycin use.
