Lorcaserin hydrochloride
Product Description
Lorcaserin hydrochloride
CAS number： 1431697-94-7
Molecular formula：C11H15Cl2N
Molecular weight： 232.14900
Packing: 1kg/bag or 25kg/drum
Valid time: 2 years
Specification:
ITEMS | Specification | RESULT |
Appearance | white or off-white powder | off-white powder |
Identification | HPLC retention time | Conforms |
Melting Point | 225-229 ℃ | 226 ℃ |
Loss on drying | ≤1.0% | 0.43% |
Residue on ignition | ≤0.5% | 0.13% |
Residual Solvents | Ethanol≤0.5% | 0.11% |
EA≤0.5% | 0.06% | |
Related Substances | Single impurity ≤0.5% | 0.21% |
Total impurity ≤1.0% | 0.39% | |
Assay (HPLC) | ≥99.0 % | 99.6% |
Conclusion | Conforms to Enterprise Standard | |
Function:
Lorcaserin hcl is an FDA-approved prescription weight-loss medication that, when used with diet and exercise, can help some overweight adults with a weight-related medical problem, or obese adults, lose weight and keep it off. It is not known if Lorcaserin hcl when taken with other prescription, over-the-counter, or herbal weight-loss products is safe and effective. It is not known if Lorcaserin hcl changes your risk of heart problems, stroke, or death due to heart problems or stroke.
Lorcaserin is a selective 5-HT2C receptor agonist, and in vitro testing of the drug showed reasonable selectivity for 5-HT2C over other related targets. 5-HT2C receptors are located almost exclusively in the brain, and can be found in the choroid plexus, cortex, hippocampus, cerebellum, amygdala, thalamus, andhypothalamus. The activation of 5-HT2C receptors in the hypothalamus is supposed to activate proopiomelanocortin(POMC) production and consequently promote weight loss through satiety. This hypothesis is supported by clinical trials and other studies. While it is generally thought that 5-HT2C receptors help to regulate appetite as well as mood, and endocrine secretion, the exact mechanism of appetite regulation is not yet known. Lorcaserin has shown 100x selectivity for 5-HT2C versus the closely related 5-HT2B receptor.
Application:
Lorcaserin hcl is an FDA-approved prescription weight-loss medication that, when used with diet and exercise, can help some overweight adults with a weight-related medical problem, or obese adults, lose weight and keep it off.
lorcaserin hydrochlorideis a serotonin 2C receptor agonist. It has been shown to decrease food consumption and promote sa tiety by selectivelyactivating serotonin 2C receptors in the brain.
Lorcaserin hcl is specifically indicated as an adjunct to a reduced-calorie diet andincreased physical activity for chronic weight management in clinically obeseadults (BMI of 30 kg/m2 or greater) and overweight adults (BMI of 27 kg/m2 orgreater) with at least one weight-related comorbid condition.
Lorcaserin hcl is supplied as a tablet designed for oral administration. The recommendeddose is one 10mg tablet twice daily. Use of Lorcaserin hcl should be discontinued if 5%weight loss is not achieved by week 12 of treatment.